Han-Wei Shih, Ph.D. (he/him/his)
Assistant Professor
Dr. Han-Wei Shih is a molecular and cell biologist. His lab investigates how the second messengers cAMP and Ca²⁺ control stage transitions in the waterborne parasite Giardia, using advanced molecular and cell biology approaches.
Education
- Pennsylvania State University- University Park, State College, PA, USA
- Ph.D. Cell Biology
Courses
- BBIO 200 Introductory Biology II
- BIO 372 Stem Cells
- BIO375 Molecular Biology
- BIO 495 Investigative Biology
Teaching Interests
Cell and Molecular Biology
Research and Scholarship Interests
Cell and Molecular Biology
- Shih HW, Alas GCM, Paredez AR. Unraveling the role of cAMP signaling in Giardia: insights into PKA-mediated regulation of encystation and subcellular interactions. mSphere. 2024 Nov 21;9(11):e0072324.
- Shih HW, Alas GCM, Paredez AR. Encystation stimuli sensing mediated by adenylate cyclase AC2-dependent cAMP signaling in Giardia. Nat Commun. 2023 Nov 9;14(1):7245.
- Shih HW, Alas GCM, Paredez AR. A cell-cycle-dependent GARP-like transcription repressor regulates the initiation of differentiation in Giardia. Proc Natl Acad Sci USA. 2022. May 31;119(22).
- Thomas EB, Sutanto R, Johnson RS, Shih HW, Alas GCM, Krtková J, MacCoss MJ, Paredez AR. Staging Encystation Progression in Giardia lamblia Using Encystation-Specific Vesicle Morphology and Associating Molecular Markers. Front Cell Dev Biol. 2021 Apr 27;9:662945.
- Michaels SA*, Shih HW*, Zhang B, Navaluna ED, Zhang Z, Ranade RM, Gillespie JR, Merritt EA, Fan E, Buckner FS, Paredez AR, Ojo KK. Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model. J Antimicrob Chemother. 2020 May 1;75(5):1218-1227. (*co-first authors)
- Hennessey KM, Rogiers IC, Shih HW, Hulverson MA, Choi R, McCloskey MC, Whitman GR, Barrett LK, Merritt EA, Paredez AR, Ojo KK., Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum. PLoS Negl Trop Dis. 2018 Aug 6;12(8).
- Shih HW, DePew CL, Miller ND, Monshausen GB., The Cyclic Nucleotide-Gated Channel CNGC14 Regulates Root Gravitropism in Arabidopsis thaliana. Curr Biol. 2015 Dec 7;25(23):3119-25. PMID:26752079 (F1000 prime recommended by Dr. Giles Oldroyd)
- Shih HW, Miller ND, Dai C, Spalding EP, Monshausen GB., The receptor-like kinase FERONIA is required for mechanical signal transduction in Arabidopsis seedlings. Curr Biol. 2014 Aug 18;24(16):1887-92. PMID:25127214 (F1000 prime recommended by Dr. Olivier Hamant)